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Synergistic activation of SAPK1/JNK1 by two MAP kinase kinases in vitro.
Lawler S, Fleming Y, Goedert M, Cohen P. Lawler S, et al. Curr Biol. 1998 Dec 17-31;8(25):1387-90. doi: 10.1016/s0960-9822(98)00019-0. Curr Biol. 1998. PMID: 9889102 Free article.
These observations suggest that the full activation of SAPK1c in vivo may sometimes require phosphorylation by two different MKKs, providing the potential for integrating the effects of different extracellular signals. They also raise the possibility that other MAPK family …
These observations suggest that the full activation of SAPK1c in vivo may sometimes require phosphorylation by two different MKKs, pr …
Purification, auto-activation and kinetic characterization of apoptosis signal-regulating kinase I.
Pleinis JM, Davis CW, Cantrell CB, Qiu DY, Zhan X. Pleinis JM, et al. Protein Expr Purif. 2017 Apr;132:34-43. doi: 10.1016/j.pep.2017.01.002. Epub 2017 Jan 7. Protein Expr Purif. 2017. PMID: 28082061
Apoptosis signal-regulating kinase I (ASK1) is a mitogen-activated protein kinase kinase kinase (MAP3K) that activates the downstream MAP kinase kinases (MKKs) from two MAP kinase cascades: c-Jun N-terminal kinase (JNK) and p38. ...
Apoptosis signal-regulating kinase I (ASK1) is a mitogen-activated protein kinase kinase kinase (MAP3K) that activates the downstream MAP ki …
POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis.
Xu Z, Kukekov NV, Greene LA. Xu Z, et al. EMBO J. 2003 Jan 15;22(2):252-61. doi: 10.1093/emboj/cdg021. EMBO J. 2003. PMID: 12514131 Free PMC article.
This pathway consists of a sequential cascade involving activated Rac1/Cdc42, mixed-lineage kinases (MLKs), MAP kinase kinases (MKKs) 4 and 7, c-Jun N-terminal kinases (JNKs) and c-Jun, and is required for neuronal death induced by various means including nerve growth fact …
This pathway consists of a sequential cascade involving activated Rac1/Cdc42, mixed-lineage kinases (MLKs), MAP kinase kinases (MKKs) …
Expression of the MAPK kinases MKK-4 and MKK-7 in rheumatoid arthritis and their role as key regulators of JNK.
Sundarrajan M, Boyle DL, Chabaud-Riou M, Hammaker D, Firestein GS. Sundarrajan M, et al. Arthritis Rheum. 2003 Sep;48(9):2450-60. doi: 10.1002/art.11228. Arthritis Rheum. 2003. PMID: 13130464 Free article.
We therefore evaluated the interactions between the various MAP kinase components and determined their subcellular localization. METHODS: MKKs were identified by immunohistochemistry of rheumatoid arthritis (RA) and osteoarthritis (OA) synovium. ...
We therefore evaluated the interactions between the various MAP kinase components and determined their subcellular localization. METHODS: …
Regulation of JNK by MKK-7 in fibroblast-like synoviocytes.
Inoue T, Hammaker D, Boyle DL, Firestein GS. Inoue T, et al. Arthritis Rheum. 2006 Jul;54(7):2127-35. doi: 10.1002/art.21919. Arthritis Rheum. 2006. PMID: 16802349 Free article.
However, the functional hierarchy of MKK-4 and MKK-7 in FLS has not been determined. We determined the relative contributions of these MKKs by evaluating the effect of MKK-4 and MKK-7 gene knockdown in cultured FLS. ...
However, the functional hierarchy of MKK-4 and MKK-7 in FLS has not been determined. We determined the relative contributions of these MK …
A docking site in MKK4 mediates high affinity binding to JNK MAPKs and competes with similar docking sites in JNK substrates.
Ho DT, Bardwell AJ, Abdollahi M, Bardwell L. Ho DT, et al. J Biol Chem. 2003 Aug 29;278(35):32662-72. doi: 10.1074/jbc.M304229200. Epub 2003 Jun 3. J Biol Chem. 2003. PMID: 12788955 Free PMC article.
Specific docking interactions between MAPKs and their activating MAPK kinases (MKKs or MEKs) are crucial for efficient and accurate signal transmission. ...This docking site conforms to the consensus sequence for known D-sites in other MKKs and contains the first of …
Specific docking interactions between MAPKs and their activating MAPK kinases (MKKs or MEKs) are crucial for efficient and accurate s …
A Protoberberine derivative HWY336 selectively inhibits MKK4 and MKK7 in mammalian cells: the importance of activation loop on selectivity.
Kim N, Park J, Gadhe CG, Cho SJ, Oh Y, Kim D, Song K. Kim N, et al. PLoS One. 2014 Apr 23;9(4):e91037. doi: 10.1371/journal.pone.0091037. eCollection 2014. PLoS One. 2014. PMID: 24759688 Free PMC article.
This model suggested the importance of the activation loop of MKKs in HWY336 selectivity. We verified this model by mutating three critical residues within this loop of MKK4 to the corresponding residues in MKK3. ...
This model suggested the importance of the activation loop of MKKs in HWY336 selectivity. We verified this model by mutating three cr …
Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway.
Gerwins P, Blank JL, Johnson GL. Gerwins P, et al. J Biol Chem. 1997 Mar 28;272(13):8288-95. doi: 10.1074/jbc.272.13.8288. J Biol Chem. 1997. PMID: 9079650 Free article.
Members of the MAPK family include the extracellular response kinases (ERKs or p42/44(MAPK)), the c-Jun amino-terminal kinases (JNKs), and the p38/Hog 1 protein kinases. MAPKs are phosphorylated and activated by MAPK kinases (MKKs or MEKs), which in turn are phosphorylated …
Members of the MAPK family include the extracellular response kinases (ERKs or p42/44(MAPK)), the c-Jun amino-terminal kinases (JNKs), and t …
Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase cascades.
Chan-Hui PY, Weaver R. Chan-Hui PY, et al. Biochem J. 1998 Dec 15;336 ( Pt 3)(Pt 3):599-609. doi: 10.1042/bj3360599. Biochem J. 1998. PMID: 9841871 Free PMC article.
Co-expressed MAP kinase kinase (MKK)-1, MKK-4, MKK-3 and MKK-6 were activated in vivo by DeltaMAPKKK4. All of the above MKKs purified from Escherichia coli were phosphorylated and activated by DeltaMAPKKK4 immunoprecipitates in vitro. ...
Co-expressed MAP kinase kinase (MKK)-1, MKK-4, MKK-3 and MKK-6 were activated in vivo by DeltaMAPKKK4. All of the above MKKs purified …
Anthrax lethal factor-cleavage products of MAPK (mitogen-activated protein kinase) kinases exhibit reduced binding to their cognate MAPKs.
Bardwell AJ, Abdollahi M, Bardwell L. Bardwell AJ, et al. Biochem J. 2004 Mar 1;378(Pt 2):569-77. doi: 10.1042/BJ20031382. Biochem J. 2004. PMID: 14616089 Free PMC article.
Protective antigen binds to a cell-surface receptor and transports LF into the cytosol. LF is a metalloprotease that targets MKKs [MAPK (mitogen-activated protein kinase) kinases]/MEKs [MAPK/ERK (extracellular-signal-regulated kinase) kinases], cleaving them to remove a sm …
Protective antigen binds to a cell-surface receptor and transports LF into the cytosol. LF is a metalloprotease that targets MKKs [MA …